Synthesis, gastroprotective and acute toxicity of bio-isosteric derivative of diclofenac
Background and objective: Non-steroidal anti-inflammatory drugs (such as diclofenac1) had been widely prescribed for the treatment of different types of pain; however, they are not devoid of adverse effects.Therefore, synthesis of new bio-isosteric analogs4a-e of diclofenac1 with greater COX II selectivity and less gastrointestinal side effect is d